To apply settings to the current user session

The set commands sets the variable but its not persistant after reboot

set [variable_name][variable_value]

The setx command sets the variable that is persistant even after reboot

setx [variable_name][variable_value]

To apply the setting to System wide use the switch /M

setx [variable_name][variable_value]/M
ex:
setx ADSKFLEX_LICENSE_FILE 27001@server-flexlm /M